Integration of popular advertising platforms.

Management of lists of frequently asked questions and their answers.

Manage tasks, assign them, manage timelines.

Create a BlogRoll widget for one of the MVC Display areas.

MVC/Razor are great innovations but it would be nice to play nice with existing DotNetNuke modules and functionality where possible, as that is such a large community. Maybe just have migration docs if nothing automated made sense.

Auto creation of thumbnail on upload via wysiwyg; image resizing, rotation.

I would love better support for Powershell. I am planning to run large multi-tenant installations of orchard and need to be able to easily move tenants or entire installations of orchard from one machine to another.

The most difficult part of starting with Orchard is understanding Clay and being able to debug variables that are dynamic via Clay. Is there a way to develop a VS extension to assist with this?

For modules, it would be great if we could have a setting to define enabled/disabled for debug/release, which should ease deployment issues greatly and improve performance. Modules would ideally come with a recommended default. For example, Shape Tracing would have release always set to false.

Mind map of relationships between queries, projections, etc in admin. Should have a check-list-box of Part/ContentType/etc that will show/hide those items on the mind map. Should be clear what items are orphans. Of course caveat will be those items that are referenced only in custom code. e.g. select Query & Projection and should be able to see query & projection mind-map "boxes" with connectors between those that are referencing the other. Query box could also show count or red outline if an exception occurred. Just a start that could see a lot of potential down the road

Add setting to configure timezone offset for when your hosting provider is in different timezone as you.
Even better if date times in the system is stored in GMT to help when you're migrating to different hosting provider in different timezones.

Integration of audio files into media gallery.

An advanced Knowledge Base module.
Would be great for companies that can take advantage of the cms users to let them update documentation in a KB for customers.